Pigs in Space?
For example, fruit flies were launched into space on a US V2 rocket, in 1947 to explore the effects of radiation exposure at high altitudes.
The Russians sent frogs and guinea pigs in to space in 1961 and France sent rats and the USA sent chimps in to space in the same year.
And of course, there are the fictional animals who went in to space. Who can forget the classis "Pigs in Space" scenes from The Muppet Show?